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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can decrease panobinostat degrees by ~70% and bring on remedy failure.pentobarbital will minimize the extent or result of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Cauti